Effect of sex hormones on the thioridazine-induced inhibition of conditioned avoidance response in the rat.

松 木 勝彦 ・岩本 多喜男 In the preceding paper, it was shown that the rat became tolerant to some psycho tropic drugs when blockage of the conditioned avoidance response was estimated as an index of tranquillizing activity (1). In the course of these studies, a statistically signi ficant difference was obtained between male and female rats in the development of tolerance upon the repeated administration of chlordiazepoxide and thioridazine. The purpose of the present study was to determine whether sex hormones are primarily con cerned with this apparent sex difference in the development of the drug tolerance.